Lucille is also the guitar played by Ryusuke, a main character from the manga/anime series Beck. It is a Gibson Les Paul with bullet holes in the body. Lucille, and its history, are based heavily on that of B. B. King's guitar of the same name. B. B. King was playing at a juke joint in the 1950s when a fire broke out. The fire was started by two men who were fighting over a woman named "Lucille". During their fight, they knocked over the bucket of burning kerosene used for heat. When King escaped the building, he realized that he had left his guitar in the burning building. He ran back inside to get it and after learning of what happened, he named his guitar, and every guitar he owned after, "Lucille" to remind himself not to do it again.
Lucille's owner in the show, sonny boy waters, is probably the amalgamation of several influential Blues musicians such as Sonny Boy Williamson II, Muddy Waters and Robert Johnson. Robert Johnson's death shares similarities with Sonny Boy's, having been shot and poisoned for fooling around with a married woman, while performing at a dance. Eric Clapton called Johnson "the most important blues musician who ever lived," fitting in even more with the information from the series.